A study of the parents of 100 pairs of twins and more than 700 single-born babies revealed significant differences in the two sets of mommies and daddies. Watch out, Brangelina!

Here's what was revealed at the annual meeting of the European Society of Human Reproduction and Embryology in Barcelona. Some highlights from the Science Daily article include:

• The mothers of (in-vitro) twins had fewer symptoms of depression before the birth than did mothers of twins conceived spontaneously.

• Fathers of twins showed more depression, anxiety, social dysfunction and sleeping problems than fathers with single babies.

• Experts believe that the shock of an unexpected extra baby, combined with added pressure to provide for another child, are some of the reasons why they are depressed.

• Researchers found that mothers of twins were twice as likely to feel depressed and one third more likely to be anxious than other moms.

• Because of these studies, doctors may start encouraging single embryo pregnancies.

Let's see--parents with twins get less sleep, more whining and crying, hundreds more diaper changes and meals to feed, as well as extra doctor appointments and being puked on... isn't it a given they'd feel a little blue?

See our celebrity parents of multiples gallery to see who else may have cause to worry.